Cancer Systems Biology Workshop at Wake Forest University School of Medicine

Webtool for Model Analysis
http://adam.vbi.vt.edu

Polynomials for ERBB2 model, you can copy and paste the polynomials into ADAM.
f1 = x13*x15*x18*x19*x20+x13*x15*x18*x19+x13*x15*x18*x20+x13*x15*x19*x20+x13*x18*x19*x20+x15*x18*x19*x20+x13*x15*x18+x13*x15*x19+x13*x18*x19+x15*x18*x19+x13*x15*x20+x13*x18*x20+x15*x18*x20+x13*x19*x20+x15*x19*x20+x18*x19*x20+x13*x15+x13*x18+x15*x18+x13*x19+x15*x19+x18*x19+x13*x20+x15*x20+x18*x20+x19*x20+x13+x15+x18+x19+x20
f2 = x3*x4*x5+x3*x4+x4*x5+x4
f3 = x2*x10*x12+x2*x10+x2*x12+x10*x12+x2+x10+x12+1
f4 = x1*x9*x10*x12+x1*x9*x12+x9*x10*x12
f5 = x2*x6*x10*x12+x2*x6*x10+x2*x6*x12+x2*x10*x12+x6*x10*x12+x2*x6+x2*x10+x6*x10+x2*x12+x6*x12+x10*x12+x2+x6+x10+x12+1
f6 = x3*x5*x7+x3*x7+x5*x7+x7
f7 = x12
f8 = x2*x11
f9 = x1*x10+x1+x10
f10 = x13*x15*x18*x19*x20+x13*x15*x18*x19+x13*x15*x18*x20+x13*x15*x19*x20+x13*x18*x19*x20+x15*x18*x19*x20+x13*x15*x18+x13*x15*x19+x13*x18*x19+x15*x18*x19+x13*x15*x20+x13*x18*x20+x15*x18*x20+x13*x19*x20+x15*x19*x20+x18*x19*x20+x13*x15+x13*x18+x15*x18+x13*x19+x15*x19+x18*x19+x13*x20+x15*x20+x18*x20+x19*x20+x13+x15+x18+x19+x20
f11 = x4
f12 = x1*x9*x10+x1*x9+x1*x10+x9*x10+x1+x9+x10
f13 = x9*x10*x18+x9*x10+x9*x18+x10*x18+x9+x10
f14 = 1
f15 = x14
f16 = x14
f17 = x14
f18 = x16*x17
f19 = x15*x16
f20 = x15*x17

The following polynomials represent the Boolean function.

x1 =MEK1
x2 = CDK4
x3 = p21
x4 = CyclinD1
x5 = p27
x6 = CDK2
x7 = CyclinE1
x8 = pRB1
x9 = ERalpha
x10 = AKT1
x11 = CDK6
x12 = MYC
x13 = IGF1R
x14 = EGF
x15 = ERBB1
x16 = ERBB2
x17 = ERBB3
x18 = ERBB2_3
x19 = ERBB1_2
x20 = ERBB1_3

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